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Volume 13, Issue 1, Pages 45-51 (February 2003)


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Thyroid disorders in pregnancy

Joanna C Girling (Consultant Obstetrician and Gynaecologist)f1

Abstract 

The physiological changes of pregnancy and the presence of the second patient, the fetus, mean that the management of thyroid disease in pregnancy is not the same as outside pregnancy. These adaptations and differences in management will be discussed.

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Article Outline

Abstract

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FURTHER READING

1. 1 Dillon JC, Milliez J. Reproductive failure in women living in iodine deficient areas of West Africa. Br J Obstet Gynaecol. 2000;107:631–636.

2. 2 Girling JC. Thyroid disease in pregnancy. In:  de Swiet M editors. Medical Disorders in Obstetric Practice. Oxford: Blackwell; 2002;.

3. 3 Girling JC, de Swiet M. Thyroxine dosage during pregnancy in women with primary hypothyroidism. Br J Obstet Gynaecol. 1992;99:368–370. MEDLINE

4. 4 Girling JC, de Swiet. Maternal thyroid disease: a risk factor for newborn encephalopathy. Br J Obstet Gynaecol. 2001;108:769–770. CrossRef

5. 5 Momotani N, Noh JY, Ishikawa N, Ito K. Effects of propylthiouracil and methimazole on fetal thyroid status in mothers with Graves' hyperthyroidism. J Clin Endocrinol Metab. 1997;82:3633–3636. CrossRef

6. 6 Mortimer RH, Galligan JP, Addison RS, Roberts MS. Maternal to fetal thyroxine transmission in the human term placenta is limited by inner ring deiodination. J Clin Endocrinol Metab. 1996;81:2247–2249. CrossRef

7. 7 Pop VJ, Kuijpens JL, van Baar Al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol. 1999;50:149–155.

8. 8 Srivatsa B, Srivatsa S, Johnson KL. Microchimerism of presumed fetal origin in thyroid specimens from women: a case control study. Lancet. 2001;358:2034–2038. Abstract | Full Text | Full-Text PDF (738 KB) | CrossRef

9. 9 Tan J YL, Loh KC, Yeo G SH, Chee YC. Transient hyperthyroidism of hyperemesis gravidarum. Br J Obstet Gynaecol. 2002;109:683–688.

10. 10 Tonglet R, Bourdoux P, Minga T, Ermans AM. Efficacy of low oral doses of iodized oil in the control of iodine deficiency in Zaire. N Engl J Med. 1992;326:236–241. MEDLINE | CrossRef

West Middlesex University Hospital, Twickenham Road, Isleworth, Middlesex, TW7 6AF, UK

f1 Correspondence to: JCG. Tel.: 020 8565 5114; Fax: 020 8565 5428; E-mail: joanna.girling@wmuh-tr.nthames.nhs.uk

PII: S0957-5847(03)90306-4

doi:10.1054/cuog.2003.0306


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